Alecensa 150mg (Alectinib)

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Alecensa 150mg belongsto an antineoplastic targeted therapy. It is classified as a tyrosine kinase inhibitor anaplastic lymphoma kinase (ALK) gene mutation. Alecensa 150mg blocks certain proteins... Read more
  • In Stock:
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  • Brand: Genentech Inc
  • Trade name Alecensa 150mg
  • Substance Alectinib
  • Manufacturer Genentech Inc
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Alecensa 150mg belongsto an antineoplastic targeted therapy. It is classified as a tyrosine kinase inhibitor anaplastic lymphoma kinase (ALK) gene mutation.

Alecensa 150mg blocks certain proteins made by the ALK gene.

Alecensa 150mg is a prescription drug which is used under the supervision of medical oncologist.


Alecensa 150mg is used for the treatment of anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

Mechanism of action

Alectinib belongs tosecond-generation oral drug which selectively prevents the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is essentially used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. prohibition of ALK blocks phosphorylation and subsequent downstream activation of STAT3 and AKT leads in decreased tumour cell viability. Both Alectinib and its major active metabolite M4 demonstrate same in vivo and in vitro activity against multiple mutant forms of ALK.

ADME Properties

Absorption: maximum plasma concentration 4 hours and bioavailability of Alecensa 37%

Distribution: Alectinib has plasma proteins binding is  99%

Metabolism: Metabolized by CYP3A4 to its major active metabolite M4, the main circulating moieties in plasma, total radioactivity 76% constituting.

Elimination: In oral administration, radioactivity 98% was excreted in feces. 84% dose was excreted in the feces unchanged Alectinib.

Half-life is 33 hours

Dosage and administration

Non- Small Cell Lung Cancer

The recommended dose is 600mg PO BID until disease progression or unacceptable

Renal impairment patients dose is 450mg orally twice daily

Alecensa is administrated with food

Side effects

Alecensa causes some side effects while administrating certain condition as follows


Muscle pain






Trouble breathing

Shortness of breath 



Drug interaction

No pharmacokinetic interactions with Alecensa 150mg needed dosage adjustment have been observed.




Embryo-fetal toxicity

Based on data from animal studies and its mechanism of action, Alecensa can cause fetal harm when administered to pregnant women.

When administration of Alecensa, Symptomatic bradycardia may have resulted; control heart rate and blood pressure regularly.

Alecensa may causes serious myalgia and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;

Renal impairment occurred during Alecensa treatment; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.


Based on studies of animal and mechanism of action, Alecensa 150mg will cause fetal harm when given to pregnant women

Advice the female not to become pregnant while on treatment with Alecensa


During treatment with Alecensa, advise the women not to breastfed to infants


Store at below 300C

Keep the drug in its original container

Missed dose

If the patient forgets totake a dose of ALECENSA, then should not to take an extra dose, but before taking the next dose, have the missed dose at the regular time, skip the missed dose. 

  • Trade name Alecensa 150mg
  • Substance Alectinib
  • Manufacturer Genentech Inc
  • Packaging 224 tablets
  • Country of origin India
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