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Lenangio 25mg consist of an active substance known as Lenalidomide which is considered as thalidomide derivative and it is originated from Generic Revlimid. Lenangio 25mg belongs to Immunomodulatory agent which has both anti-angiogenic & anti-cancer activity. Lenangio 25mg is a naturally established compound which plays important role in myeloma at first, later it is used for hematological disorders like myelodysplastic syndromes.
The most important therapeutic indication of Lenangio 25mg is given below as follows;
Lenangio 25mg is not suggested in chronic lymphocytic leukemia.
Lenangio 25mg (Generic Revlimid), is a thalidomide analog. Pharmacological action of Lenalidomide remains to be fully characterized, however, it has been described that Lenalidomide prohibits the expression of cyclooxygenase-2 (COX-2), but not COX-1, in vitro. In vivo, it activates tumor cell apoptosis directly and indirectly by prevention of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity
The absorption occurs very quickly. The high plasma concentration-time occurs between 0.5 to 6 hours after drug intake.
Lenangio 25mg is bounds to human plasma protein at relatively 30%
The metabolism of Lenalidomide is appears in limited range, mostly unchanged form of Lenalidomide is a major circulating substance present in the human body.
There are two major metabolites like;
Not more than 5% of parent form is present in the circulation.
The mainly elimination of Lenalidomide is occurs through renally.
Nearly 82% of radioactive dose is eliminated in urine within 24 hours; the two metabolites are excreted in 4.6% & 1.8%.
The half-life period of Lenalidomide in healthy person is 3 hours; whereas in myeloma & MDS or MCL is 3 to 5 hours
The potency of Lenalidomide is not evaluated in pediatric patients with the age of <18 years.
The recommended dosage is 10mg of Lenalidomide should be taken as a single dose.
In CrCl 30 to 60ml/min: 5mg of Lenalidomide should be suggested for once a day.
In CrCl <30ml/min: 2.5mg PO as a single dose
In CrCl >60ml/min: No dosage adjustment is required
The therapy should be followed by combining of Lenangio 25mg with dexamethasone as a single dose.
The recommended dose of Lenangio 25mg is 25mg should be given as a single dose on day 1 to 21 of repeated 28-day cycles.
The dosage of dexamethasone;
For first 4 cycles;
40mg of dexamethasone should be recommended on days 1 to 4; 9 to 12; & 17 to 20 of each 28-day cycles.
Then followed by 40mg should be given as single dose, days 1 to 4 every 28 days
Age >75 years: 20mg of dexamethasone is recommend, on day 1, 8, 15 & 22 of each 28 cycle.
The recommended dosage of Lenangio 25mg is 25mg should be administered orally as a single dose.
CrCl 30 to 60ml/min: 10mg PO single dose
CrCl <30ml/min: 15mg should be recommend as a single dose.
In ESRD: 5mg should be given
Lenangio 25mg (Generic Revlimid) should be taken with or without food.
Lenangio 25mg capsules should not be opened, broken or chewed.
It should be administered with whole water.
There is no special treatment for over dosage of Lenalidomide; In case of this condition patient must be provided with adjuvant therapy and monitor the signs & symptoms frequently.
Lenangio 25mg is concomitant use with digoxin causes higher the plasma concentration of Lenalidomide leads to increase the adverse effects. There is no pharmacokinetic changes occurs during this concomitant of Lenalidomide with warfarin, but patients may get an alteration in prothrombin time & INR. To avoid this condition, monitor the values frequently during this combinational therapy.
Erythropoietic drugs or some other medicines that may elevate the exposure of thrombosis like estrogen containing treatment. This type of concomitant treatment should be used cautiously to reduce the risk factors.
Lenalidomide is contraindicated to pregnancy condition, may cause fetal damage Some hyper sensitivity reactions like Stevens Johnsons syndrome, angioedema may occur, due to patients may contraindicate to the components present in Lenangio 25mg tablets.
Lenalidomide is contraindicated to pregnancy conditions.
Constant hepatic function test should be done, before and during the therapies. In this condition, treatment should be postponed and continue if required.
This condition may occur in patients who undergone Lenalidomide therapy, in CLL & lymphoma have chance of getting inflammation on lymph nodes, fever, pain, & rash
In this condition, patients must be monitored carefully, and precaution should be providing.
Lenangio 25mg treatment should be withheld or discontinue in case of angioedema, rash, bullous rashes.
In MDS, Lenangio 25mg is used as a monotherapy, in this condition there is a chance of getting increased exposure of DVT & PE.
Lenangio 25mg causes thrombocytopenia and neutropenia, patients receiving Lenangio 25mg for MDS should be completely examine by investigating blood counts weekly for first 8 weeks. In MM patients should be monitored with counting blood cells for every 2 weeks for first 12 weeks and then monthly afterwards. In this condition, dose reduction is applicable.
Pregnancy category: X Lenangio 25mg should not be recommended in pregnancy condition
Breastfeeding should not be recommended. The initial dose of Lenalidomide is depending upon the creatinine clearance value and for the patients in dialysis.
Lenangio 25mg tablets should be stores at 20oC to 25oC; excursion between 15oC to 30oC. Keep the container away from heat, moisture & light
The missed dose of Lenangio 25mg should be avoided and follow the regular dosing schedule. Must consult the doctor.
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